Immunology Flipped Course • iBiology

Resources for Immunology Flipped Course

Leading scientists explain the fundamentals of the inflammatory response, B and T cell development, autoimmunity, and plant immunology. This course is designed as a graduate-level introduction to immunology.

Title	Video	Concepts	Duration	Video Downloads	Transcript	PDF Resources (Educators Only)
Session 1: Introduction: Which Cells Are the Players? Starting with a basic review of the immune cells, this session provides a general overview of the immune system and its activation. With: Brittany Anderton, Ira Mellman Share this session with your students						All Course Materials for this Session (Educators only)
The Cells of the Immune System	Watch on iBio Watch on YouTube	Review of the immune cells, innate and adaptive immune systems, antigen presentation, T cell activation via MHC-I and MHC-II molecules.	00:05:54	Hi-Res Low-Res Subtitled: English	View Transcript
The Immune System	Watch on iBio Watch on YouTube	Recognition of self- versus non-self, dendritic cells, lymphoid tissues, innate versus adaptive immunity, inflammation, macrophages, Toll-Like Receptors, B cells, T cells and T cell receptors, CD8/CD4 T Cells, and T cell communication with dendritic cells	00:35:31	Hi-Res Low-Res Subtitled: English	View Transcript
Cellular Basis of the Immune Response	Watch on iBio Watch on YouTube Note: Please watch original video from time 31:57 to 38:30.	MHC Class I molecules and activation of CD8+ cytotoxic T cells	00:06:33	Hi-Res Subtitled: English	View Transcript
Session 2: The Inflammatory Response: Activation of the Innate Immune System This session will help you understand the molecular basis of inflammation. In summary, the body has specialized immune cells (sensor cells) that detect homeostasis disturbances and activate a series of responses that help clear the inflection and restore homeostasis. With: Ruslan Medzhitov Share this session with your students						All Course Materials for this Session (Educators only)
Introduction to Inflammation	Watch on iBio Watch on YouTube	Homeostasis, inflammation, sensors, effector cells, mediators, and resolution	00:36:30	Hi-Res Low-Res Subtitled: English	View Transcript
Inflammation and Disease Tolerance: Surviving Acute Illness	Watch on iBio Watch on YouTube	Pathology of inflammation. Explains the connection between insulin/glucose homeostasis and the organismal response to viral and bacterial infections.	00:30:35	Hi-Res Low-Res Subtitled: English	View Transcript
Session 3: Bridging Innate & Adaptive Immunity This session provides an overview of regulation of the acquired immune system and the crosstalk that happens between innate and adaptive immunity. With: Ruslan Medzhitov, Ira Mellman Share this session with your students						All Course Materials for this Session (Educators only)
Antigen Presentation and Dendritic Cells	Watch on iBio Watch on YouTube Please watch original video from time 00:00 to 25:33 (Clip Link).	Link between innate immunity and adaptive immunity, MHC-I & MHC-II mediated activation, function and maturation of dendritic cells, antigen cross-presentation, activation of T cells by dendritic cells, T cell tolerance, and regulatory T cells (Tregs)	00:25:28	Hi-Res Subtitled: English Spanish	View Transcript
Antigen Presentation and Dendritic Cells	Watch on iBio Watch on YouTube Please watch original video from time 35:07 to 49:42 (Clip Link).	Link between innate immunity and adaptive immunity, MHC-I & MHC-II mediated activation, function and maturation of dendritic cells, antigen cross-presentation, activation of T cells by dendritic cells, T cell tolerance, and regulatory T cells (Tregs)	00:14:37	Hi-Res Subtitled: English Spanish	View Transcript
The Role of Toll-Like Receptors in the Control of Adaptive Immunity	Watch on iBio Watch on YouTube	Immune recognition of self versus non-self, identification and characterization of Toll-Like Receptors, activation of adaptive immunity	00:20:58	Hi-Res Low-Res Subtitled: English	View Transcript
Session 4: Molecular View of Adaptive Immunity This session provides a molecular overview of T cell receptor (TCR) activation and signaling. It shows how TCRs bind to their corresponding peptide-MHC complexes to form the immunological synapse. With: Michael Dustin Share this session with your students						All Course Materials for this Session (Educators only)
The Immunological Synapse: Antigen Recognition	Watch on iBio Watch on YouTube Note: Please watch original video from time 16:50 to 36:57.	T cell receptor (TCR) activation and signaling cascade, components of the immunological synapse	00:20:07	Hi-Res Low-Res Subtitled: English	View Transcript
The Immunological Synapse: Signaling and Function	Watch on iBio Watch on YouTube	Immunological synapse, role of CD45 in the activation of the immunological synapse, cancer- immunotherapy, function of actin/WASp in the immunological synapse, and synapse vs kinapse	00:30:18	Hi-Res Low-Res Subtitled: English	View Transcript
Session 5: B Cells: Development, Selection, and Function This session showcases the generation of antibody diversity (via V, D, J recombination), and the mechanisms that ensure the proper function of B cells (pre-BCR signaling and tolerance). With: Shiv Pillai, Hidde Ploegh Share this session with your students						All Course Materials for this Session (Educators Only)
Early B Cell Development: A Look at the Defining Questions in Immunology	Watch on iBio Watch on YouTube	Historical perspective of the study of immunology, antigens/antibodies, side chain hypothesis, clonal selection hypothesis, antibody structure & function, generation of antibody diversity via VDJ recombination, and tolerance.	00:37:33	Hi-Res Low-Res Subtitled: English	View Transcript
Bruton Tyrosine Kinase Signaling: The pre-B Cell Receptor and B Cell Differentiation	Watch on iBio Watch on YouTube Note: This video is optional for this session.	B cell biogenesis, allelic exclusion, discovery of pre-B cell receptor (pre-BCR), LIAR hypothesis, pre-BCR and Btk signaling cascades.	00:23:27	Hi-Res Low-Res Subtitled: English	View Transcript
Immunology: The Basics of Antibody Diversity	Watch on iBio Watch on YouTube Note: Please watch original video from time 20:30 to 38:50.	B cell development, class-switch recombination, T cell receptor recombination, MHC complex assembly, and pathogen disruption of T-cell mediated immunity.	00:18:21	Hi-Res Low-Res Subtitled: English	View Transcript
Session 6: T Cells: Development and Differentiation This session provides an overview of T cell development and differentiation. It covers two important mechanisms that prevent autoimmunity (central and peripheral tolerance) and characterizes the biogenesis and function of two specialized T cells (Tregs and Th17 cells). With: Dan Littman, Diane Mathis Share this session with your students						All Course Materials for this Session (Educators Only)
An Introduction to T Cell Tolerance	Watch on iBio Watch on YouTube Note: Please watch original video from time 2:06 to 36:39.	Central and peripheral tolerance, type-1 diabetes (example of autoimmune disease), and Treg biogenesis and function.	00:34:33	Hi-Res Low-Res Subtitled: English	View Transcript
Th17 Cells and Innate Lymphoid Cells in Barrier Defense and Inflammatory Diseases	Watch on iBio Watch on YouTube Please watch original video from time 1:55 to 31:25 (Clip Link).	T cell differentiation, characterization of CD4+ cells, and review of Th17 role in autoimmune diseases	00:29:29	Hi-Res Low-Res Subtitled: English	View Transcript
Session 7: Autoimmunity and Allergy Allergy and autoimmunity occur when immune cells are activated by non-pathogenic antigens. This session explores the molecular underpinnings of allergies and autoimmunity. With: Avery August, Diane Mathis, Ted Yednock Share this session with your students						All Course Materials for this Session (Educators Only)
Allergies and the Immune System	Watch on iBio Watch on YouTube	IgE, mast cell and basophil response to IgE, and allergic response	00:15:55	Hi-Res Low-Res Subtitled: English	View Transcript
Transcription Factor Aire Orchestrates T Cell Tolerance	Watch on iBio Watch on YouTube	APS-1 Syndrome, AIRE protein role in T cell tolerance, AIRE expression/localization, and importance of Tregs for APS-1	00:37:23	Hi-Res Low-Res Subtitled: English	View Transcript
Discovery and Development of Natalizumab for the Treatment of Multiple Sclerosis	Watch on iBio Watch on YouTube Note: This video is optional for this session.	Introduction to multiple sclerosis (MS), EAE mouse model to study MS, 𝛼4𝛃1-Integrin, Anti-𝛼4𝛃1-Integrin experiments before & post MS manifestation, and development of Tysabri (Natalizumab)	00:34:53	Hi-Res Low-Res Subtitled: English	View Transcript
Session 8: Plant Immunity and the Evolutionary Arms Race between Host and Pathogen This session covers the basics of plant immunology and reviews two major pathways that activate the plant immune response: Effector-triggered immunity and Pattern-triggered immunity. With: Sheng-Yang He, Harmit Malik Share this session with your students						All Course Materials for this Session (Educators Only)
Introduction to Plant-Pathogen Interactions	Watch on iBio Watch on YouTube	Effector-Triggered immunity, Avr genes versus resistance genes, bacterial Type-II Secretion system, indirect recognition by R proteins, and Pattern-Triggered immunity	00:19:28	Hi-Res Low-Res Subtitled: English	View Transcript
Host and Viral Evolution: Molecular Evolutionary Arms Race Between Primate and Viral Genomes	Watch on iBio Watch on YouTube	Molecular arms races between primate and viral genomes, host evolution, host-virus interactions, natural selection of mutations, and PKR signaling evolution across primates	00:32:50	Hi-Res Subtitled: English	View Transcript
Arabidopsis thaliana-Pseudomonas syringae interaction: The effect of climate in plant disease	Watch on iBio Watch on YouTube Note: This video is optional for this session.	Arabidopsis - P. Syringae model system of infection, role of environment (temperature & humidity) in plant disease, pattern-triggered immunity & effector inhibition, and water soaking as a symptom of bacterial infection in leaves	00:29:07	Hi-Res Low-Res Subtitled: English	View Transcript
Session 9: The Immunology of Organ Transplantation In this session, you will learn about the major types of transplantation, evaluate the immune cells involved in organ rejection, and understand the basics of transplantation tolerance (long-term graft acceptance without the long-term use of immunosuppressants). With: Megan Sykes Share this session with your students						All Course Materials for this Session (Educators Only)
Introduction to Transplantation: The Immune Response to Allo- and Xenotransplantation	Watch on iBio Watch on YouTube	Allo- and Xenotransplantation, immune cells involved in transplantation rejection, HLA matching, acute & chronic rejection, direct & indirect T Cell response, immunosuppressive drugs, and hematopoietic cell transplantation	00:32:19	Hi-Res Low-Res Subtitled: English	View Transcript
Taming and Tracking the Human Alloresponse	Watch on iBio Watch on YouTube	Transplantation tolerance, and mixed chimerism	00:37:40	Hi-Res Low-Res Subtitled: English	View Transcript
Xenotransplantation	Watch on iBio Watch on YouTube Note: This video is optional for this session.	Xenotransplantation, 𝛼1,3-Gal, genetically engineered pigs for organ transplants, xenograft rejection, tolerance induction, mixed chimerism, CD47 signaling/macrophages in xenotransplantation	00:31:32	Hi-Res Low-Res Subtitled: English	View Transcript
Session 10: The Immune Response in Health and Disease This session evaluates two examples of the interaction between pathogens and the human immune system: human papillomavirus (HPV) and tuberculosis pathogenesis. With: Lalita Ramakrishnan, John Schiller Share this session with your students						All Course Materials for this Session Educators Only
Why Do HPV Virus-Like Particle Vaccines Work So Well?	Watch on iBio Watch on YouTube	Human Papillomavirus (HPV), HPV susceptibility to neutralizing antibodies, B cell receptor/Virus-like particle complex, and importance of viral infection timeline	00:34:26	Hi-Res Low-Res Subtitled: English	View Transcript
An Introduction to Tuberculosis: The Pathogenic Personality of the Tubercle Bacillus	Watch on iBio Watch on YouTube	Overview of tuberculosis (TB), TB prevalence worldwide, life cycle of TB, TB pathogenesis (infection of macrophages & granulomas), efflux pumps, and TB vaccine	00:34:44	Hi-Res Low-Res Subtitled: English	View Transcript
The Troublesome Tubercle in Tuberculosis	Watch on iBio Watch on YouTube Note: This video is optional for this session.	TB bacterium's use of granuloma to attract macrophages and increase infectivity, Mycobacterium marina - a model to study TB in zebrafish, granuloma promotes growth of the TB bacteria, and expansion of disease via macrophage apoptosis	00:29:42	Hi-Res Low-Res Subtitled: English	View Transcript