Wiesel received his medical degree from the Karolinska Institute in Sweden and continued his training at Johns Hopkins University Medical School. There he began a collaboration with Dr. David Hubel, which led to a major breakthrough in the understanding of the visual cortex and ultimately resulted in them be awarded the Nobel Prize in Physiology or Medicine in 1981. Wiesel moved to Harvard University in 1959 and in 1983 he moved to Rockefeller University where he was president from 1991 until 1998.
Wiesel was elected as a Foreign Member of Royal Society in 1982, and received the National Medal of Sciences in 2005.